The research team, led by LI Bei from the Changchun Institute of Optics, Fine Mechanics and Physics, designed a variable cross-section microfluidic chip using photocuring 3D printing. This innovative approach allows for precise control of fluid flow and significantly reduces the sample volume required for viscosity measurements.
The device operates by recording changes in pressure and flow velocity over time, enabling accurate viscosity measurements with just 25 µl of sample and completing each experiment in under two minutes. Published in Analyst, the study highlights the potential of this new device in various fields, including biopharmaceuticals, biomedical research, and industrial applications. Traditional viscosity measurement methods, such as capillary and rotational viscometers, often require large sample volumes and direct contact with the sample, leading to potential contamination and waste. The new microfluidic viscometer addresses these issues by utilizing non-contact optical imaging technology, making it suitable for measuring the viscosity of precious biopharmaceutical samples and other micro-volume fluids.
The study demonstrated the device's effectiveness by testing various fluids, including glycerol-water solutions, Tween 20-water solutions, sucrose solutions, and bovine serum albumin (BSA) solutions. The results showed excellent correlation with measurements from a commercial viscometer, confirming the accuracy and reliability of the new system. Additionally, the device successfully measured the viscosity of non-Newtonian fluids, such as polyethylene oxide (PEO) solutions, which exhibit shear-thinning behavior.
The use of 3D printing technology in fabricating the microfluidic chip not only improved the precision of the device but also reduced production costs and time. The researchers employed a layered printing approach to create open flow channels, ensuring smooth surfaces and accurate dimensions. This method allows for rapid prototyping and customization of microfluidic chips, making it accessible for various research and industrial applications.
The development of this microfluidic viscometer has implications for the biopharmaceutical industry, where precise viscosity control is crucial for drug formulation and delivery. The device's ability to measure viscosity with minimal sample volume and high accuracy makes it an invaluable tool for researchers and manufacturers. Furthermore, the integration of 3D printing technology opens up possibilities for designing multifunctional microfluidic devices that can perform complex biochemical analyses and diagnostic tasks.
In conclusion, this study presents an approach to viscosity measurement, combining microfluidic technology with 3D printing to create a cost-effective, efficient, and accurate viscometer. The device's potential applications extend beyond biopharmaceuticals, offering opportunities for advancements in various industries, including cosmetics, food, and advanced lubricants.
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